Alpha-PiHP (α-PiHP) is a synthetic cathinone belonging to the pyrrolidine class of compounds. Structurally and functionally similar to alpha-PVP and alpha-PHP, Alpha-PiHP has gained popularity in analytical and pharmacological research due to its strong stimulant-like activity.
Despite its increasing use in laboratories, Alpha-PiHP remains strictly intended for research purposes. This guide will break down its mechanism, effects, safety considerations, and how it compares to related compounds.
Chemical Overview of Alpha-PiHP
- IUPAC Name: 1-Phenyl-2-(pyrrolidin-1-yl)hexan-1-one
- Molecular Formula: C16H23NO
- Class: Synthetic cathinone, stimulant
- Structure: Pyrrolidine ring + phenyl group + ketone function
Structural Relatives:
- α-PVP (alpha-Pyrrolidinopentiophenone)
- α-PHP (alpha-Pyrrolidinohexanophenone)
- α-PHiP (longer alkyl-chain variant)
These compounds differ primarily in carbon chain length, affecting potency, duration, and receptor binding affinity.
Mechanism of Action
Although not fully characterized in human trials (and not intended for human use), research on Alpha-PiHP suggests the following actions:
- Monoamine Reuptake Inhibition
It primarily inhibits dopamine and norepinephrine reuptake, leading to increased levels of these neurotransmitters in in vitro studies. - Stimulant Activity
α-PiHP shows potent psychostimulant effects, comparable to other substituted cathinones, making it useful for studying CNS stimulation and abuse potential.
Common Effects Observed in Research Settings
While specific pharmacological profiles vary, researchers have reported the following in in vitro and animal model studies:
| Effect | Description |
|---|---|
| Dopaminergic Activity | Increased locomotor activity and dopamine levels |
| Stimulant Effect | Alertness, hyperactivity in animal models |
| Sympathomimetic | Elevated heart rate, blood pressure (in animal tests) |
| Abuse Liability Study | Evaluated for reinforcing effects and addictive potential |
Comparison Table: α-PiHP vs. Related Compounds
| Compound | Structural Difference | Potency | Duration | Research Focus |
|---|---|---|---|---|
| α-PiHP | Hexyl chain | High | Moderate | CNS stimulant analysis |
| α-PVP | Pentyl chain | Very High | Long | Abuse potential study |
| α-PHP | Hexyl chain + ketone | High | Long | SAR exploration |
Legal and Safety Considerations
Alpha-PiHP is not approved for human or veterinary use. It should only be used by qualified researchers in a controlled lab environment.
- Legal Status:
Alpha-PiHP is unscheduled in some countries, but may be considered a controlled substance analog depending on local laws. Always verify local regulations before purchase or handling. - Safety Handling:
Use PPE (gloves, goggles, lab coat) and store in a cool, dry environment. Avoid direct exposure or unauthorized access.
Final Thoughts
Alpha-PiHP is a valuable compound for research into CNS stimulants and monoamine reuptake inhibition mechanisms. Its structural similarity to α-PVP and α-PHP makes it ideal for comparative pharmacology and structure-activity relationship (SAR) studies.
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