MDPHP (3′,4′-Methylenedioxy-α-pyrrolidinohexanophenone) is a synthetic cathinone derivative belonging to the pyrrolidine class of stimulants. With structural similarities to MDPV and α-PHP, it has become a compound of interest in the fields of neuropharmacology and behavioral science research.
At ResearchChemicalsOutlet.com, we offer high-purity MDPHP powder (freebase form) for research-only applications.
What is MDPHP?
MDPHP is part of the substituted cathinone family, known for its strong dopamine reuptake inhibition and sympathomimetic effects. As a freebase, this version of MDPHP is more lipophilic, which may influence its volatility and bioavailability in animal or in vitro models.
Chemical Overview:
- IUPAC Name: 1-(2H-1,3-benzodioxol-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one
- Molecular Formula: C17H25NO3
- Class: Synthetic cathinone, stimulant
- Form: Freebase powder (not salt form)
Mechanism of Action
MDPHP is believed to function primarily as a:
- Dopamine Transporter (DAT) Inhibitor
- Norepinephrine Transporter (NET) Inhibitor
This results in increased levels of monoamines in the synaptic cleft, producing enhanced locomotion and arousal in laboratory settings.
Common Effects Observed in Research
| Effect | Description |
|---|---|
| CNS Stimulation | Increased locomotor activity (animal studies) |
| Wakefulness | Sleep suppression observed in behavioral models |
| Elevated Heart Rate | Typical of sympathomimetic stimulants |
| Dopamine Elevation | High extracellular dopamine in test subjects |
| Abuse Liability Modeling | Used in studies of reinforcing behavior |
MDPHP vs. Similar Cathinones
| Compound | Structure | Potency | Duration | Primary Use in Research |
|---|---|---|---|---|
| MDPHP | Hexyl chain + methylenedioxy | High | Medium | Dopamine reuptake studies |
| MDPV | Pentyl chain + methylenedioxy | Very High | Long | Abuse potential modeling |
| α-PHP | Hexyl chain, no MD ring | High | Medium | CNS stimulation |
Why Choose the Freebase Form?
The freebase version of MDPHP differs from its hydrochloride or salt counterparts in solubility and volatility. It’s often preferred for:
- Inhalation model testing
- Solvent-based extractions
- Non-aqueous system compatibility
⚠️ Always use proper lab safety protocols when handling freebase forms due to potential volatility.
Safety & Legal Disclaimer
- NOT FOR HUMAN CONSUMPTION.
- For laboratory research use only.
- Researchers must comply with local legal regulations concerning cathinones and related compounds.
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