ADB-BUTINACA (ADB-B) is one of the most prominent indazole-based synthetic cannabinoids studied in pharmacological research today. As a highly potent CB1 and CB2 receptor agonist, ADB-B is commonly used in studies focused on endocannabinoid signaling, receptor binding affinity, and structure-activity relationships (SAR).
At ResearchChemicalsOutlet.com, we provide high-purity ADB-B powder for research purposes only.
Chemical Overview
- IUPAC Name: N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-butyl-1H-indazole-3-carboxamide
- Molecular Formula: C18H26N4O2
- Class: Synthetic cannabinoid
- Form: Powder
- Activity: Full agonist at CB1 and CB2 receptors
Mechanism of Action
ADB-B functions as a potent full agonist at cannabinoid receptors:
- CB1 receptor: Primarily found in the brain; modulates mood, perception, and motor function.
- CB2 receptor: Located mainly in peripheral tissues; plays a role in immune response and inflammation.
Compared to Δ9-THC (natural THC), ADB-B has significantly stronger binding affinity and longer-lasting effects in animal and cellular models.
Research Applications of ADB-B
| Application | Description |
|---|---|
| Receptor Affinity Testing | Evaluating CB1/CB2 selectivity and potency |
| Signal Pathway Mapping | Understanding GPCR-linked responses |
| Toxicological Profile Studies | Exploring metabolic breakdown and synthetic toxicity |
| Structure-Activity Relationship | Comparing analogs like ADB-FUBINACA, MDMB-BUTINACA |
| Behavioral Pharmacology | Measuring cannabinoid-induced responses in test subjects |
Comparison with Other Synthetic Cannabinoids
| Compound | CB1 Affinity | Duration | Potency | Structural Notes |
|---|---|---|---|---|
| ADB-B / ADB-BUTINACA | Very High | Long | High | Indazole base with butyl group |
| ADB-FUBINACA | Very High | Medium | Very High | Fluorinated chain |
| MDMB-CHMINACA | High | Short | Moderate | Ester-linked, less stable |
Safety and Legal Disclaimer
ADB-B is for laboratory research use only and is not for human or veterinary consumption.
- Legal Status: May be controlled under synthetic cannabinoid bans in some countries. Always confirm local regulations.
- Handling: Use proper PPE. Store in a cool, dark, and dry environment in tightly sealed containers.
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Final Thoughts
ADB-B / ADB-BUTINACA stands out among synthetic cannabinoids due to its high receptor affinity, long duration, and structural versatility. It’s a top choice for researchers exploring the mechanisms of the endocannabinoid system.